GE HEALTHCARE XDR-50 / XDR50, Xcellerex Single-Use Bioreactor System Xcellerex XDR 50 single-use stirred-tank bioreactors Xcellerex XDR single-use bioreactor systems provide scalable and robust stirred-tank performance for up to 50 L in both cGMP a
A new generation of larger-scale stirred disposable bioreactors has appeared in commercial manufacture over the last three years. This trend is led by Thermo Fisher's single-use bioreactor (SUB), available in sizes up to 1,000 L, followed by Xcellerex's single-use XDR bioreactor, available in sizes up to 2,000 L.
This application note shows the feasibility of monoclonal antibody (MAb) production in fed-batch processes using the single-use Xcellerex™ XDR-200 stirred-tank and ReadyToProcess WAVE™ 25 rocking bioreactor systems. Cell expansion was performed in a 15 L rocking bioreactor culture to seed a 200 L stirred-tank bioreactor culture. To compare the performance of ReadyToProcess WAVE 25 with .
2020-5-7 · Perfusion cell culture using WAVE Bioreactor Systems 2/10 and 20/50 Cultivation of CHO and HEK293 cells in PEI transfection reagent using WAVE Bioreactor . compared to the settings used for smaller Cellbag bioreactors. For example, use an initial speed of 15 rpm and angle of 5° with a Cellbag-50L rather than the settings given above.
2017-2-17 · antibody production in a fed-batch process using single-use stirred-tank and rocking bioreactor systems (1). Results Table 1 and Figure 3 show the cell growth, viability, and yield results. Cell growth and viability were similar for both bioreactors. mAb yields from the parallel productions were 5.0 and 4.9 g/L for XDR-200 and ReadyToProcess .
Bioreactor Systems Thermo Fisher Scientific US. Thermo Scientific offers a range of bioreactors perfectly suited for mammalian cell culture and microbial fermentation applications that span process development clinical trials and large scale commercial biomanufacturing The bioreactor portfolio offers options from 1 L glass bioreactors to 2 000 L single use bioreactors
2019-5-24 · The cells from (3) 3000 ml spinner flasks were used to inoculate an XDR-50 bioreactor (Fig. 1). The initial culture volume was 32 l with the inoculum density of 2 × 10 5 cells/ml and 3 g/l of Cytodex-1 microcarriers. The XDR-50 bioreactor was set to a temperature of 37 °C, and the agitation rate was set to 40 rpm with down pumping mode.
Single Use Bioreactors Market by Product, Type, End User . 7 Single use Bioreactor Market, By Type (Page No. - 63) 7.1 Introduction 7.2 Stirred-Tank Single use Bioreactor 7.3 Wave-Induced Single use Bioreactor 7.4 Bubble-Column Single use Bioreactor 7.5 Other Single use Bioreactor . 8 Single use Bioreactor Market, By Type of Cell (Page No. - 73) 8.1 Introduction 8.2 Mammalian Cells 8.3 .
2020-7-17 · Single use bioreactor 50–1000 Tankliner Stirred Thermo-Fischer (Hyclone) (UT, USA) <40 [105] XDR single-use bioreactor 40–2000 Tankliner Stirred GE Healthcare/Xcellerex (MA, USA) <20 [106] Mobius® CellReady 50–200 Tankliner Stirred Merck Millipore (MA, USA) <70 [107] Nucleo single-use bioreactor
Stirred-tank bioreactors; Stirred-tank bioreactor systems; Enjoy Free Shipping on most orders placed online – Terms Apply. Refine by. Refine by . Filter products: more filters Done {{category.title}} {{category.title}} Clear Filters Showing results .
WAVE Bioreactor systems offer a convenient and cost-effective, single-use bioreactor solution for seed train and small-scale culturing up to 100 L working volume. Xcellerex XDR stirred tank bioreactor systems are designed to minimize scale-up risks and facilitate the goal of achieving a robustness, purity, and potency of the final manufacturing .
2020-8-18 · Arguably the most ambitious work toward single‑use fermentation is the Xcellerex XDR‑50 MO fermentor system from GE Healthcare, which reports growth performance comparable with that of conventional stainless‑steel fermentors. But the maximum cell density for this 30‑L single‑use system is barely double that the Celltainer system (6 .
Stirred-tank bioreactors. Scalable XDR bioreactor platform with up to 5:1 turndown and single-use bags. Sizes from 2.5 L to 2000 L working volume.
2019-12-11 · Application note: Engineering characterization of the single-use Xcellerex XDR-500 stirred-tank bioreactor system, GE Healthcare, KA4969250918AN (2018) 4. Application Note: Engineering characterization of the single-use Xcellerex XDR-1000 stirred-tank bioreactor system, GE Healthcare, 29242384 Edition AA, (2017) 5.
Single-use disposable technologies in the manufacturing of biopharmaceuticals Advantages and limitations of single-use manufacturing Single-use systems for protein drug substance production process: key features, current scales and vendors Disposables reduce cost of clinical manufacturing and co-locating manufacturing.
Allegro STR Single-use Stirred Tank Bioreactors The Allegro STR bioreactor family combines Pall's bioprocess engineering expertise, cell culture know-how and our drive for quality into a series of single-use bioreactors that deliver consistent and scalable cell culture performance across the range.
The same when scaled up to a modified stirred tank bioreactor with PUF foam support matrix yielded 97.28 mg/L (6.4 mg/g DW) of the compound 54. To overcome the mass transfer problems associated with the submerged type of bioreactors gas phase bioreactors were developed by the authors for A. indica hairy root cultivation. The nutrients were made .
2017-11-30 · Xcellerex™ XDR‑500 MO and XDR‑50 MO stirred‑tank fermentor systems. 2 KA332161117AN . XDR‑50 MO and XDR‑500 MO systems. In both single‑use systems, an induction temperature of 30°C was reached within 0.5 h, with . All goods and services are sold subject to the terms and conditions of sale of the company within GE Healthcare .
2007-12-21 · stirred tank, Xcellerex 1,000L stirred tank bioreactor Integration Challenge: liners, connectors, sensors, filters, controllers Scale Up Challenge: avoid stressing bag seams, small scale modeling system that scales to 10,000L Large Scale Cell Culture Bioreactors
A new generation of larger-scale stirred disposable bioreactors has appeared in commercial manufacture over the last three years. This trend is led by Thermo Fisher's single-use bioreactor (SUB), available in sizes up to 1,000 L, followed by Xcellerex's single-use XDR bioreactor, available in sizes up to 2,000 L.
Modular and scalable XDR single-use bioreactors provide exemplary stirred-tank bioreactor performance from process development to production. XDR single-use bioreactors are a modular platform with scalable working volumes up to 2000 L. XDR bioreactors offer smooth transfer from process development to manufacturing scale, with the convenience and cost-effectiveness of single-use technology.
2013-5-21 · In both systems, the HF was a ReadyToProcess™ filter (RTPCFP-2-E-4X2MS, GE Healthcare) with 0.2 μm pore size, 1 mm lumen, 60 cm nominal flow path length, 850 cm 2 filter area, and 50 polysulfone fibers and ReadyMate™ disposable aseptic connectors were used (HFs were water rinsed for 30 min, allowed to stand in water overnight, and .
Single Use Bioreactors Market by Product, Type, End User . 7 Single use Bioreactor Market, By Type (Page No. - 63) 7.1 Introduction 7.2 Stirred-Tank Single use Bioreactor 7.3 Wave-Induced Single use Bioreactor 7.4 Bubble-Column Single use Bioreactor 7.5 Other Single use Bioreactor . 8 Single use Bioreactor Market, By Type of Cell (Page No. - 73) 8.1 Introduction 8.2 Mammalian Cells 8.3 .
Single-Use Bioreactors - Cell Culture | Pall Corporation. Allegro™ XRS 25 Bioreactor System: for high cell density cell culture of mammalian cells, and for insect cell culture; from 2 to 25L Allegro STR Single-Use Stirred Tank Bioreactor Family : scalable single-use bioreactor family, from 10L to 2000L; applications include mAbs, gene therapy and adherent cells grown on microcarriers
2019-11-14 · GE Healthcare GE Healthcare is headquartered in the US and offers products through the following business units: Healthcare Systems, Life Sciences, and Healthcare Digital. . XDR 10 single .
2017-11-30 · Xcellerex™ XDR‑500 MO and XDR‑50 MO stirred‑tank fermentor systems. 2 KA332161117AN . XDR‑50 MO and XDR‑500 MO systems. In both single‑use systems, an induction temperature of 30°C was reached within 0.5 h, with . All goods and services are sold subject to the terms and conditions of sale of the company within GE Healthcare .
Single-use Bioreactors | Cytiva, formerly GE Healthcare . Stirred-tank bioreactor systems designed for scalability and robustness. Xcellerex XDR fermentor systems. Stirred-tank fermentor systems meeting the unique needs of microbial cultures. RELATED INFORMATION. Articles and blog posts.
2020-8-12 · HyClone CDM4HEK293 medium. GE Healthcare, 29264715, Edition AA (2017). 4. Application note: Adenovirus production in single-use Xcellerex XDR-10 bioreactor system. GE Healthcare, KA874021017AN (2017). 5. Brochure: Fortem – a single use platform film built for bioprocess. GE Healthcare, 29240489, Edition AA (2016). 6.
2018-10-1 · Single-use stirred tank bioreactors. . Xcellerex XDR™ 10–2000: Stirred: GE Healthcare Life Sciences . only a few studies dealing with SUB-related questions of cultivation with immobilized cells and mixing properties in stirred tank bioreactor systems .
The Thermo Scientific HyPerforma Single-Use Bioreactor (S.U.B.) is widely adopted in process development (PD), clinical trials, and cGMP cell culture production. The design and features of the HyPerforma S.U.B. have been steadily improved since its launch in 2006 to meet the increasing performance demands required by current cell culture processes.